Pharmacology Ketamine is a phencyclidine derivative that produces a unique dissociative anesthetic (cataleptic) state rather than a global depression of the central nervous system (CNS). 1,2 Ketamine is generally supplied as a racemic mixture R (-) and S (+) isomers. The S (+) isomer possesses a faster clearance rate and 3-4 times the analgesic activity. 1 It is highly lipid soluble with a …

