First study to compare ketamine therapies for patients with severe …

In a new study, investigators compared the effects of repeated intravenous (IV) ketamine and intranasal (IN) esketamine in patients with treatment-resistant depression and found both reduced depression severity, with IV ketamine showing relatively earlier and greater improvements.

https://news.harvard.edu/gazette/story/2025/09/first-study-to-compare-two-ketamine-therapies-for-patients-with-severe-depression/