Ketamine for Depression, but at What Cost? A Review of Ketamine’s …

September 12, 2025

This review examines ketamine’s neurotoxic potential across preclinical and clinical studies. The authors synthesized data from preclinical models, then integrated findings from human clinical trials of esketamine and observational studies in recreational users. Animal studies have found that repeated or high-dose subanesthetic ketamine administration results in consistent excitotoxic …

https://psychiatryonline.org/doi/full/10.1176/appi.ajp.20250276

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